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抑制剂 & 化合物

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天然产物

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重组蛋白

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Cat. No. Product Name Target Signaling Pathways
T75838 PDZ1 Domain inhibitor peptide TFA

PDZ1 Domain inhibitor peptide TFA,一种环状肽,以 β-Ala 内酰胺侧链为接头,专一性靶向 PSD-95 的 PDZ1 域。此化合物能干扰 GluR6/PSD-95 间的相互作用,通过与 GluR6 的 C 末端竞争,抑制其在 PDZ1 域的结合。

化合物

PDZ1 Domain inhibitor peptide TFA
Cat.No: T75838
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T4S0145 Corylifol A

Corylinin,补骨脂异黄酮A

hCE; STAT; UGT JAK/STAT signaling; Metabolism; Stem Cells
Corylifol A (Corylinin) 是补骨脂中的一种天然产物,可抑制IL-6 诱导的STAT3激活和磷酸化,IC50值为0.81 μM。

天然产物

Corylifol A
Cat.No: T4S0145
Synonym: Corylinin,补骨脂异黄酮A
Target: hCE, STAT, UGT
Cat. No. Product Name Species Expression System
TMPJ-00652 PSD-95 Protein, Rat, Recombinant (His)

PSD95,SAP90,Disks large homolog 4,SAP-90,PSD-95...

Rat E. coli
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain,3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the be...
TMPY-03750 CRIPT Protein, Human, Recombinant (His)

HSPC139,SSMDF,cysteine-rich PDZ-binding protein

Human E. coli
CRIPT, also known as cysteine-rich PDZ-binding protein, belongs to the CRIPT family. It interacts with TUBB1. CRIPT also interacts strongly with the PDZ3 domain of members of the DLG4 family. It is involved in the cytoskeletal anchoring of DLG4 in excitatory synapses. CRIPT is highly conserved from mammals to plants and binds selectively to the third PDZ domain (PDZ3) of PSD-95 via its C terminus. n heterologous cells, CRIPT causes a redistribution of PSD-95 to microtubules. In brain, CRIPT colo...

重组蛋白

PSD-95 Protein, Rat, Recombinant (His)
Cat.No: TMPJ-00652
Species: Rat
Expression System: E. coli
CRIPT Protein, Human, Recombinant (His)
Cat.No: TMPY-03750
Species: Human
Expression System: E. coli
TargetMol Loading
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